3D-SHAPER® Technical & Clinical validation

3D-SHAPER technology has been validated by comparing measures and images computed by 3D-SHAPER and QCT [1].

Cortical thickness distribution (left)

Frontal slices showing bone density values (right)

Obtained by 3D Shaper® and QCT for three patients

Mean shape accuracy: 0.9 mm

  • [1] Humbert et al., “3D-DXA: Assessing the Femoral Shape, the Trabecular Macrostructure and the Cortex in 3D from DXA images.,” IEEE Trans. Med. Imaging, vol. 36, no. 1, pp. 27–39, Jan. 2017.

    © 2017 IEEE

Numerous clinical studies have been presented/published to date and there are several more currently in progress – investigating the added-value of 3dimensional bone parameters in the context of diagnosis/fracture identification, secondary osteoporosis, muscle/bone relationships. A wide variety of study subjects are at the core of such investigations:

  • Cortical and trabecular bone changes under different osteoporosis drug – published
  • Association with fracture - completed
  • Fracture prediction – on-going
  • Chronic kidney disease – completed
  • Spinal cord injury - published
  • High bone mass – published
  • Age-related reference database - completed
  • Hyperparathyroidism – completed
  • Human Immunodeficiency Virus (HIV) – on-going
  • Diabetes – completed & on-going
  • Glucocorticoïd-induced osteoporosis – on-going
  • Breast cancer - completed
  • Muscle/Bone relationship – several studies completed and published

Overview

Discover 3D-SHAPER® embedded technology, 3D-DXA, that allows to generate a patient-specific 3D model of the hip from a standard 2D DXA scan, and to perform measurements of both cortical and trabecular bone density.

3D-DXA algorithms-based technology rely on a population database of QCT scans, to create a shape and density 3D model, that is then applied onto a patient hip DXA scan. In a second step, the cortex is segmented in order to separate the cortical from the trabecular bone. This allows to get a patient-specific 3D model of the hip and to perform specific measurements of the cortical and trabecular bone.

  • SHARE: